Synthesis and photodynamic effect of 3-substituted methyl pyropheophorbide-a derivatives as novel photodynamic therapeutic agents for cancer treatment

Autor:	Sang Bong Lee, Young Key Shim, Tae Heon Lee, Bora Lee, Da-Sol Lee, Kil Soo Kim, Ye Ri Han, Hye Jeong Kim, Dong-Won Kim, Yong Hyun Jeon, Su-Jin Park, Young Kyu Song
Rok vydání:	2022
Předmět:	Pyropheophorbide a Chemistry General Chemical Engineering medicine.medical_treatment Photodynamic therapy Pyrazole Combinatorial chemistry Tumor tissue In vitro Cancer treatment chemistry.chemical_compound In vivo Chlorin medicine
Zdroj:	Journal of Industrial and Engineering Chemistry. 105:513-519
ISSN:	1226-086X
DOI:	10.1016/j.jiec.2021.10.009
Popis:	The unique ability of chlorophyll derivatives to accumulate in tumor tissues and cause a photodynamic effect under laser radiation has been successfully used in photodynamic therapy (PDT). Previous research on modified peripheral substituents in chlorophyll showed that the presence and position of substituents in chlorin derivatives remarkably affect biological activities. Herein, we synthesized methyl pyropheophorbide-a (MPPa) derivatives, which are chlorophyll-a derivatives with heterocyclic aromatic substituents or pyrazole moieties on the peripheral positions. Then, we examined the PDT effects of these new derivatives in vitro and in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::409ec09d0448c8d3281ca6f0ae10f6a2 https://doi.org/10.1016/j.jiec.2021.10.009 Zobrazit plný text záznamu Full Text from ScienceDirect