Microwave enhanced greener synthesis of indazoles via nitrenes

Autor:	Maghar S. Manhas, Ajay K. Bose, Deepu Varughese
Rok vydání:	2006
Předmět:	Microwave chemistry Chemistry Nitrene Organic Chemistry Drug Discovery Microwave irradiation Nitro chemistry.chemical_element Photochemistry Biochemistry Nitrogen Microwave Grinding
Zdroj:	Tetrahedron Letters. 47:6795-6797
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2006.07.062
Popis:	Non-traditional methods (grinding, water-based biphasic reactions, microwave chemistry) were used for the preparation of Schiff bases from several amines and 2-nitrobenzaldehydes. These nitro compounds were allowed to react with triethyl phosphite under microwave irradiation for the generation of nitrenes that underwent insertion reactions to form indazoles. This procedure constitutes an energy-efficient, greener chemistry version of the Cadogan reaction for nitrene-based formation of nitrogen heterocycles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::409a5eb29c0836a3aed9f9fd69adc090 https://doi.org/10.1016/j.tetlet.2006.07.062 Zobrazit plný text záznamu Full Text from ScienceDirect