Effects of Long-Term High-Altitude Hypoxia on Ioslated Fetal Ovine Coronary Arteries

Autor: Virginia M. Stiffel, Raymond D. Gilbert, Felizabel C. Garcia
Rok vydání: 2000
Předmět:
Zdroj: Journal of the Society for Gynecologic Investigation. 7:211-217
ISSN: 1071-5576
DOI: 10.1177/107155760000700404
Popis: To examine the effects of long-term high-altitude hypoxia on the contractile properties of isolated fetal coronary arteries. Maximal contractile responses (Tmax) to 90 mmol/L KCl and the thromboxane A2 mimetic U46619 were measured in proximal (PLCx) and distal left circumflex (DLCx), left anterior descending (LAD), and right coronary arterial (RCA) rings from high-altitude and control fetuses. Paired studies were conducted with and without nitric oxide synthase (NOS) inhibitors, Nω-nitro-l-arginine and Nω-nitro-l-arginine ester. In high-altitude fetuses, 90 mmol/L KCl Tmax responses in both intact and NOS-blocked rings decreased by ∼62% in PLCx, ∼59% in DLCx, ∼57% in LAD, and ∼47% in RCA (n = 9–18/group; P > .05). High-altitude vessels also exhibited decreased sensitivity to U46619. NOS blockade potentiated Tmax to U46619 in the high-altitude RCA segments and augmented Tmax to U46619 in high-altitude RCA compared with its treated control counterpart (P > .05). These results suggest that nitric oxide influences the pharmacologic responsiveness of the RCA to U46619. Furthermore, long-term high-altitude hypoxia significantly alters the contractile capabilities of fetal coronary arteries. These observations may partiall explain the maintained redistribution of cardiac output to the fetal heart during exposure to long-term high-altitude hypoxia.
Databáze: OpenAIRE
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