Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process
| Autor: | Benno Schneider, Shoko Takenaga, Torsten Wagner, Thomas Schnitzler, Manfred Biselli, E. Erbay, Michael J. Schöning |
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| Rok vydání: | 2015 |
| Předmět: |
Materials science
Biocompatibility Microfluidics Nanotechnology Surfaces and Interfaces Lab-on-a-chip Light-addressable potentiometric sensor equipment and supplies Condensed Matter Physics Chip Surfaces Coatings and Films Electronic Optical and Magnetic Materials law.invention Laboratory flask law Materials Chemistry Potentiometric sensor Electrical and Electronic Engineering Biosensor |
| Zdroj: | physica status solidi (a). 212:1347-1352 |
| ISSN: | 1862-6300 |
| DOI: | 10.1002/pssa.201532053 |
| Popis: | A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation. |
| Databáze: | OpenAIRE |
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