Falsely Increased Thyroid-stimulating Hormone Concentrations attributable to Interference from Human Anti-mouse Antibodies
| Autor: | François Parant, Dany Alcaraz-Galvain, Marie Christine Pénès, Françoise Flourié |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases biology business.industry Biochemistry (medical) Clinical Biochemistry Levothyroxine medicine.disease Endocrinology Mouse monoclonal antibody Internal medicine Immunology biology.protein medicine Antibody business Increased thyroid-stimulating hormone hormones hormone substitutes and hormone antagonists Uveitis medicine.drug Hormone |
| Zdroj: | Clinical Chemistry. 48:2289-2289 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/48.12.2289 |
| Popis: | We describe a case of a spurious increase in serum thyroid-stimulating hormone (TSH) attributed to a circulating human anti-mouse antibody (HAMA) in a two-site mouse monoclonal antibody-based assay. A 71-year-old woman on long-term levothyroxine therapy was referred for investigation of uveitis. Her serum TSH had been maintained within the usual reference interval for more than a decade. The initial TSH value by an immunometric method (assay A) on the Dimension RxL analyzer (Dade Behring) was 7.5 mIU/L (reference interval, 0.34–4.82 mIU/L). Because … |
| Databáze: | OpenAIRE |
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