The Impact of Sleep Deprivation on Molecular Mechanisms of Memory Consolidation in Rodents
| Autor: | Judith C. Kreutzmann, Jennifer C. Tudor, Ted Abel, Christopher C. Angelakos |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Molecular signaling business.industry Specific time Cognition 03 medical and health sciences Sleep deprivation 030104 developmental biology 0302 clinical medicine Neuroplasticity Medicine Memory consolidation medicine.symptom business Neuroscience 030217 neurology & neurosurgery Sleep loss |
| Zdroj: | Cognitive Neuroscience of Memory Consolidation ISBN: 9783319450643 |
| DOI: | 10.1007/978-3-319-45066-7_5 |
| Popis: | Loss of sleep leads to deleterious effects on cognitive function, with memory being significantly impaired when rodents are sleep deprived during the first 5–6 h following learning. Recent findings suggest that lack of sleep during this specific time period after learning alters molecular signaling pathways critical for the formation of memories. Several molecular mechanisms underlying impaired cognition caused by sleep deprivation have been described. In this review, we will discuss the proposed molecular mechanisms underlying memory consolidation affected by sleep deprivation, which includes timing of sleep deprivation and the molecular signaling pathways involved. |
| Databáze: | OpenAIRE |
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