Adsorption/Desorption Characteristics of cis-Platin on Mercapto-Silylated Silica Surfaces

Autor:	Nicola Hüsing, David Avnir, Sharon Fireman-Shoresh
Rok vydání:	2001
Předmět:	Adsorption desorption Chemistry Cooperativity Surfaces and Interfaces Condensed Matter Physics Ormosil Cancer treatment Cis platin Adsorption Desorption Electrochemistry General Materials Science Spectroscopy Hydrophobic silica Nuclear chemistry
Zdroj:	Langmuir. 17:5958-5963
ISSN:	1520-5827 0743-7463
DOI:	10.1021/la010513z
Popis:	High-dose cancer treatment with cis-platin (CP, cis-[Pt(NH3)2Cl2]), although of therapeutic value, is limited by its toxicity. Fast removal of excess drug shortly after administration and site-specific drug release are potential partial solutions of this problem. As a first stage toward these solutions, several adsorption/desorption properties of CP have been determined and analyzed. The main adsorbent selected for this study was silica silylated with (3-mercaptopropyl)trimethoxysilane (MPTS). The properties of this mercapto-derivatized silica (SiSH) were compared with an organically modified silica sol−gel material (Ormosil) using MPTS as modifier and with nonderivatized silica (SiOH). Although Langmuirian at first glance, a more detailed analysis of the adsorption isotherm of the CP/SiSH system revealed a cooperative mechanism of adsorption, namely, an increase in adsorption affinity with coverage. This cooperativity was detected by employing a coverage-dependent adsorption-equilibrium constant. Active ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4086e488ff5b9c501de003d5ee28d2e0 https://doi.org/10.1021/la010513z Zobrazit plný text záznamu