A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei

Autor:	W R Weiss, J A Berzofsky, R A Houghten, M Sedegah, M Hollindale, S L Hoffman
Rok vydání:	1992
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 149:2103-2109
ISSN:	1550-6606 0022-1767
Popis:	Clone B is a cytotoxic T cell clone induced by immunization with Plasmodium yoelii sporozoites which recognizes an epitope on both the P. yoelii and Plasmodium berghei circumsporozoite proteins. It is CD8, uses the V beta 8.1 TCR, and is Kd restricted. When adoptively transferred, it protects mice against infection by both species of malaria sporozoites, and this protection is dependent on IFN-gamma. Clone B cells are more broadly reactive and protective than previously described murine T cell clones against malaria. Clone B may be an important model for immune protection against the spectrum of variant parasites in nature.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4085faf3414f7d55ed56813fb90bd5a9 https://doi.org/10.4049/jimmunol.149.6.2103 Zobrazit plný text záznamu