Synthesis and Characterization of 2-Pyrazoline Derivatives and their in silico and in vitro Studies on Antimicrobial and Anticancer Activities

Autor:	Raja Chinnamanayakar, M.R. Ezhilarasi, S. Rathinamanivannan, K. Megha, Ashok Kumar
Rok vydání:	2019
Předmět:	0303 health sciences 03 medical and health sciences 010405 organic chemistry Chemistry General Chemistry Pyrazoline derivatives Antimicrobial 01 natural sciences Combinatorial chemistry In vitro 030304 developmental biology 0104 chemical sciences
Zdroj:	Asian Journal of Chemistry. 31:2191-2196
ISSN:	0975-427X 0970-7077
Popis:	The new series of 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-yl)butan-1-one derivatives were synthesized by cyclization method using biphenyl chalcone with n-butyric acid and hydrazine hydrate. The synthesized 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-yl)butan-1-one derivatives chemical structures were confirmed from spectral data such as FT-IR, 1H and 13C NMR. 2-Pyrazoline derivatives were docked with bacterial (1UAG) and breast cancer (1OQA) protein. Based on high binding affinity score, the best compound was subjected to in vitro anticancer activity by MTT assay. Also, antimicrobial activity were studied for synthesized 2-pyrazoline derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::406d0db96863472d4a0246b044e3e51e https://doi.org/10.14233/ajchem.2019.22082 Zobrazit plný text záznamu