Characterization of Escherichia coli RNase H Discrimination of DNA Phosphorothioate Stereoisomers

Autor:	Erik Funder, Steffen Schmidt, Peter Hagedorn, Łukasz J. Kiełpiński
Rok vydání:	2021
Předmět:	biology Chemistry medicine.disease_cause Biochemistry Chemical synthesis chemistry.chemical_compound Drug Discovery Antisense oligonucleotides Genetics medicine biology.protein Molecular Medicine RNase H Molecular Biology Escherichia coli DNA
Zdroj:	Nucleic Acid Therapeutics. 31:383-391
ISSN:	2159-3345 2159-3337
Popis:	Phosphorothioate (PS) modification of antisense oligonucleotides (ASOs) is a critical factor enabling their therapeutic use. Standard chemical synthesis incorporates this group in a stereorandom ma...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::405d02d83c216cebd7ee86ce928d723a https://doi.org/10.1089/nat.2021.0055 Zobrazit plný text záznamu