Characterization of Escherichia coli RNase H Discrimination of DNA Phosphorothioate Stereoisomers
Autor: | Erik Funder, Steffen Schmidt, Peter Hagedorn, Łukasz J. Kiełpiński |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Nucleic Acid Therapeutics. 31:383-391 |
ISSN: | 2159-3345 2159-3337 |
Popis: | Phosphorothioate (PS) modification of antisense oligonucleotides (ASOs) is a critical factor enabling their therapeutic use. Standard chemical synthesis incorporates this group in a stereorandom ma... |
Databáze: | OpenAIRE |
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