Epstein-Barr virus-associated primary central nervous system lymphoma in a patient with adult T-cell leukemia / lymphoma
| Autor: | Tatemi Todaka, Tetsuaki Sugimoto, Masahiro Amano, Kousuke Marutsuka, Mitsuru Setoyama |
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| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Primary central nervous system lymphoma Dermatology General Medicine medicine.disease medicine.disease_cause Epstein–Barr virus Adult T-cell leukemia/lymphoma Virus Lymphoma Leukemia Immune system immune system diseases hemic and lymphatic diseases Immunology medicine business Immunodeficiency |
| Zdroj: | The Journal of Dermatology. 38:575-580 |
| ISSN: | 0385-2407 |
| DOI: | 10.1111/j.1346-8138.2010.01120.x |
| Popis: | We present a case of Epstein-Barr virus (EBV)-associated primary central nervous system lymphoma (PCNSL) arising from a patient with cutaneous-type adult T-cell leukemia/lymphoma (ATLL). Extranodal sites affected by ATLL include the skin, lung, liver, gastrointestinal tract and central nervous system (CNS). CNS involvement usually occurs as an acute and lymphoma-type ATLL. PCNSL is a rare type of tumor and the vast majority of PCNSL are of B-cell lineage. Individuals with acquired, iatrogenic or congenital immunodeficiency are at increased risk of PCNSL, which is commonly associated with EBV. In our patient, the expression of latent infection membrane protein 1 (LMP1), EBV nuclear antigen 2 (EBNA2), and EBV-encoded small RNA (EBER) in tumor cells confirmed a type III latency of EBV infection. Human T-cell lymphotropic virus type I (HTLV-I) can induce immunodeficiency before the overt development of ATLL. The HTLV-I infection led to suppression of the immune system and the development of EBV-associated PCNSL. This is the first reported case of the clinicopathological features of EBV-associated PCNSL arising from a patient with ATLL. |
| Databáze: | OpenAIRE |
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