Lipid-induced changes in protein conformation as a means to regulate the immunogenicity of antigens incorporated in tubular immunostimulating complexes
| Autor: | Natalia S. Vorobieva, O. Yu. Portniagina, Valery L. Shnyrov, Olga D. Novikova, Ludmila Davydova, E. Ya. Kostetsky, Nina M. Sanina |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
030102 biochemistry & molecular biology biology Immunogenicity Biophysics Hemagglutinin biology.organism_classification law.invention 03 medical and health sciences Cucumaria 030104 developmental biology Glycolipid Antigen Biochemistry law Porin Recombinant DNA Yersinia pseudotuberculosis |
| Zdroj: | Biophysics. 61:380-386 |
| ISSN: | 1555-6654 0006-3509 |
| Popis: | Nanoparticles of tubular immunostimulating complexes (TI-complexes), which consist of the glycolipid monogalactosyldiacylglycerol (MGDG) from marine macrophytes (macroalgae and seagrasses), the triterpene glycoside cucumarioside A2-2 from the holothurian Cucumaria japonica, and cholesterol, are a promising adjuvant carrier of antigens for modern subunit vaccines. MGDG provides a lipid matrix for the antigen incorporated in TI-complexes. This paper discusses the manner in which the physicochemical properties of MGDGs isolated from different marine macrophyte species affect the conformation of two model protein antigens (Yersinia pseudotuberculosis OmpF-like porin (YOmpF) and recombinant influenza virus hemagglutinin) incorporated in TI-complexes and how the modulating effect of MGDG may be used to improve the efficacy of vaccine preparations. |
| Databáze: | OpenAIRE |
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