| Autor: |
Amber R. Krauchunas, Matthew R. Marcello, Putiri E, Gunasekaran Singaravelu, Looper A, Xue Mei, Ahmed, Andrew Singson |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.07.07.451551 |
| Popis: |
The growing number of genes specifically required for fertilization suggests that there is a significant amount of molecular complexity at the sperm-egg interface. Thus, we have adopted a model of a “fertilization synapse” where specialized zones of interaction and multi-protein complexes mediate gamete interaction and fusion. The fertilization synapse is likely to be composed of both trans and cis protein-protein interactions at the surface of each gamete. Mutations in the Caenorhabditis elegans spe-36 gene result in a sperm-specific fertility defect. Surprisingly, spe-36 encodes a secreted EGF-motif containing protein that functions cell autonomously. Despite the fact that morphology and migratory behavior of spe-36 sperm are indistinguishable from wild-type sperm, spe-36 sperm make close contact with oocytes but fail to fertilize them. The genetic requirement for a secreted sperm-derived protein for fertilization is novel and represents a paradigm-shifting discovery in the molecular understanding of fertilization. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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