Astaxanthin modulates age-associated mitochondrial dysfunction in healthy dogs1
| Autor: | J. Zhang, G. A. Reinhart, M. G. Hayek, Bridget D Mathison, Boon P. Chew, Jean Soon Park |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
biology Membrane permeability Chemistry Cytochrome c General Medicine Glutathione Mitochondrion medicine.disease_cause chemistry.chemical_compound Endocrinology Astaxanthin Internal medicine Coenzyme Q – cytochrome c reductase Genetics medicine biology.protein Cytochrome c oxidase Animal Science and Zoology Oxidative stress Food Science |
| Zdroj: | Journal of Animal Science. 91:268-275 |
| ISSN: | 1525-3163 0021-8812 |
| Popis: | Young (2.97±0.01 yr; 8.16±0.15 kg BW) and geriatric (10.71±0.01 yr; 9.46±0.18 kg BW) healthy female Beagle dogs (n=14/age group) were fed 0 or 20 mg astaxanthin daily for 16 wk to examine modulation of mitochondrial function. Fasted blood was sampled on wk 0, 8, and 16. Mitochondria membrane permeability, ATP production, cytochrome c oxidase/reductase, and number were assessed in leukocytes whereas astaxanthin uptake, glutathione, superoxide dismutase, nitric oxide, 8-hydroxy-2'-deoxyguanosine, 8-isoprostane, and protein carbonyl were measured in plasma. Aging increased (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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