Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents
| Autor: | Muhammad Ntale, Chukwudi Onyeka Okonkwo, Ambrose Amamchukwu Akunne, Ezera Agwu, Steve Ogbonnia, Ahmed Adebowale Adedeji, Jennifer Chibuogwu Ebosie, J.O.C. Ezeonwumelu, Julius Kihdze Tanayen, Frederick Byarugaba |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Tuberculosis biology medicine.drug_class business.industry Urinary system Antibiotics Analgesic biology.organism_classification medicine.disease Gastroenterology Lesion 03 medical and health sciences Pneumonia 030104 developmental biology 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Internal medicine Bidens pilosa medicine medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Pharmacology & Pharmacy. :175-192 |
| ISSN: | 2157-9431 2157-9423 |
| DOI: | 10.4236/pp.2018.96014 |
| Popis: | Oral lesions, diarrhoea, Pneumocystis carinii pneumonia, tuberculosis and urinary tract infections are some of the opportunistic infections (OIs) which arise when the CD4 cells of the HIV/AIDS patient fall below 200 cells/mm3. HIV/AIDS infection complications include tissue damage from oral lesions accompanied with pains. Pain is a disagreeable sensory and sensitive experience associated with actual or potential tissue damage. This condition requires immediate treatment with analgesics and antibiotics. However, the inability of rural dwellers to afford readily available drugs is a consequence for using herbs like Bidens pilosa whose local usefulness in the management of oral lesions of HIV/AIDS has not been proven scientifically. Therefore, the objective of this study was to provide the scientific basis in rats for the traditional healers’ use of Bidens pilosa leaves’ extracts in managing pain associated with oral lesions of HIV/AIDS patients in South Western Uganda. Assessment of the analgesic effects of Bidens pilosa was conducted using acetic acid in mice, formalin-induced pain and tail flick methods in rats. Both aqueous and ethanolic extracts of the leaves of Bidens pilosa produced statistically significant dose dependent inhibition of acetic acid induced pain, non dose dependent pain reduction in formalin induced pain, (p < 0.05; student t-test) and non dose dependent tail withdrawal pattern (p < 0.05, Multivariate ANOVA test). Hence, we conclude that extracts of Bidens pilosa have an analgesic basis for their local use in treatment of oral lesions associated pain in HIV/AIDS patients in South-Western Uganda. |
| Databáze: | OpenAIRE |
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