| Autor: |
Tadashi Hasegawa, Jiro Hashimoto, Toshiaki Tanaka, Naoya Masumori, Hiroshi Kitamura, Yoshinori Ikehata, Megumi Hirobe, Taiji Tsukamoto |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
International Cancer Conference Journal. 3:169-172 |
| ISSN: |
2192-3183 |
| DOI: |
10.1007/s13691-013-0140-8 |
| Popis: |
Epithelioid angiomyolipoma (EAML) is a rare variant of angiomyolipoma (AML) with potentially malignant characteristics such as local recurrence and distant metastasis. Although a component of EAML can be seen in typical AML, the biologic relationship between EAML and typical benign AML is not fully understood. We report a sporadic case of renal EAML that arose in a typical AML which was present for 23 years. A 74-year- old woman had been followed-up for AML in the right kidney with regular radiographic examinations for 21 years. After a 2-year interruption of evaluation, she visited the hospital again, complaining of right flank pain. Computed tomography revealed a rapidly growing solid tumor adjacent to the typical AML under surveillance. Histological examination of a radical nephrectomy speci- men revealed that a fat-rich typical AML and EAML with nuclear atypia and mitosis composed 30 and 70 % of the tumor, respectively. Local recurrence and distant metasta- sis developed 3 months after surgical resection. The met- astatic tumors grew rapidly despite chemotherapy with the MAID (mesna, adriamycin, ifosfamide, and dacarbazine) regimen, and she died 4 months after the surgery. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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