Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent
Autor: | Huy Luong Xuan, Phuong M Chau, Anh M Thuy, Truong Thanh Tung, Tam D Duc |
---|---|
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
chemistry.chemical_classification Antitumor activity Antifungal 030102 biochemistry & molecular biology medicine.drug_class Organic Chemistry Clinical Biochemistry Antimicrobial peptides Druggability Peptide Computational biology Antimicrobial Biochemistry 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry medicine Antibacterial activity Lead compound |
Zdroj: | Amino Acids. 53:843-852 |
ISSN: | 1438-2199 0939-4451 |
Popis: | Polybia-MP1 is a well-known natural antimicrobial peptide that has been intensively studied recently due to its therapeutic potential. MP1 exhibited not only potent antibacterial activity but also antifungal and anticancer properties. More importantly, MP1 shows relatively low hemolytic activity compared to other antimicrobial peptides having a similar origin. Thus, besides investigating possible mechanisms of action, great efforts have been invested to develop this peptide to become more "druggable". In this review, we summarized all the chemical approaches, both success and failure, that using MP1 as a lead compound to create modified analogs with better pharmacological properties. As there have been thousands of natural AMPs found and deposited in numerous databases, such useful information in both the success and failure will provide insight into the research and development of antimicrobial peptides and guiding for the next steps. |
Databáze: | OpenAIRE |
Externí odkaz: |