In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design
| Autor: | Sharon R Lewin, Jori Symons, Ewa Czuba-Wojnilowicz, Frank Caruso, Christina Cortez-Jugo, Paula M. Cevaal, Abdalla Ali |
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| Rok vydání: | 2021 |
| Předmět: |
Chemistry
Lymphocyte medicine.medical_treatment T cell General Engineering General Physics and Astronomy 02 engineering and technology Immunotherapy 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease 01 natural sciences 0104 chemical sciences medicine.anatomical_structure In vivo Drug delivery Cancer research medicine Nanomedicine T-cell lymphoma General Materials Science 0210 nano-technology Ex vivo |
| Zdroj: | ACS Nano. 15:3736-3753 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/acsnano.0c09514 |
| Popis: | T cells play an important role in immunity and repair and are implicated in diseases, including blood cancers, viral infections, and inflammation, making them attractive targets for the treatment and prevention of diseases. Over recent years, the advent of nanomedicine has shown an increase in studies that use nanoparticles as carriers to deliver therapeutic cargo to T cells for ex vivo and in vivo applications. Nanoparticle-based delivery has several advantages, including the ability to load and protect a variety of drugs, control drug release, improve drug pharmacokinetics and biodistribution, and site- or cell-specific targeting. However, the delivery of nanoparticles to T cells remains a major technological challenge, which is primarily due to the nonphagocytic nature of T cells. In this review, we discuss the physiological barriers to effective T cell targeting and describe the different approaches used to deliver cargo-loaded nanoparticles to T cells for the treatment of disease such as T cell lymphoma and human immunodeficiency virus (HIV). In particular, engineering strategies that aim to improve nanoparticle internalization by T cells, including ligand-based targeting, will be highlighted. These nanoparticle engineering approaches are expected to inspire the development of effective nanomaterials that can target or manipulate the function of T cells for the treatment of T cell-related diseases. |
| Databáze: | OpenAIRE |
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