Regio- and stereoselective epoxidation of chiral 1,4-cyclohexadienes

Autor:	Arthur G. Schultz, Fook S. Tham, Roger E. Harrington
Rok vydání:	1992
Předmět:	Steric effects Diene Stereochemistry Organic Chemistry Cyclohexadienes Epoxide Regioselectivity Biochemistry chemistry.chemical_compound chemistry Amide Drug Discovery Electrophile Stereoselectivity
Zdroj:	Tetrahedron Letters. 33:6097-6100
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)60015-1
Popis:	The diastereoselectivities of epoxidations of diene amides 1b, 7 , and 9 appear to depend on steric approach control with the involvement of amide conformers analogous to that observed by X-ray diffraction studies of epoxide 8 (Figure 1). This mechanistic framework should be useful for predicting the reactivity of diene amides related to 7 with other electrophilic reagents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4002f88db10d6e09d436ab1032cc1cd6 https://doi.org/10.1016/s0040-4039(00)60015-1 Zobrazit plný text záznamu