Impaired Antibody Response toHaemophilus influenzaeType b Polysaccharide and Low IgG2 and IgG4 Concentrations in Apache Children

Autor:	Mathuram Santosham, G. Raymond Reid, Janné Almeido-Hill, Jeffrey K. Ketcham, Claudette M. Thompson, Gerda deLange, George R. Siber, Elaine H. Callahan, Andreas Morell
Rok vydání:	1990
Předmět:	Diphtheria toxin biology Tetanus business.industry Pasteurellaceae Toxoid General Medicine medicine.disease medicine.disease_cause biology.organism_classification Polysaccharide Vaccine Haemophilus influenzae Microbiology Immunization Immunology medicine biology.protein Antibody business
Zdroj:	New England Journal of Medicine. 323:1387-1392
ISSN:	1533-4406 0028-4793
Popis:	Background and Methods. Because Native American children are at much higher risk for invasive Haemophilus influenzae type b infection than white children, we compared the antibody responses to H. influenzae type b polysaccharide vaccine in healthy Apache and white children. Results. The concentrations of H. influenzae type b antibody after immunization with polysaccharide vaccine were approximately 10-fold lower in 24-month-old Apache children than in whites of a similar age (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3ffa3b4bdebf8b3e5ab14a285fcf622a https://doi.org/10.1056/nejm199011153232005 Zobrazit plný text záznamu