In Utero Stem Cell Transplantation
| Autor: | Michael R. Harrison, Esmail D. Zanjani, Alan W. Flake |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Fetus business.industry medicine.medical_treatment fungi Hematopoietic stem cell Hematopoietic stem cell transplantation Bioinformatics Clinical trial Transplantation 03 medical and health sciences Haematopoiesis 030104 developmental biology medicine.anatomical_structure In utero medicine Stem cell business |
| Zdroj: | Fetal Stem Cells in Regenerative Medicine ISBN: 9781493934812 |
| DOI: | 10.1007/978-1-4939-3483-6_17 |
| Popis: | During the last few decades, the human fetus has become a candidate for therapeutic interventions; however, most of these therapies are surgical in nature and target specific anatomic defects that benefit from prenatal intervention. In this chapter we review the rationale for cell-based in utero therapy, namely in utero hematopoietic stem cell transplantation (IUHCT). The primary rationale for IUHCT is that early introduction of cells into the pre-immune fetus can take advantage of normal hematopoietic and immunologic development, leading to allogeneic engraftment. IUHCT may offer a prenatal cure to many congenital hematopoietic diseases and be a safe, more effective alternative to postnatal hematopoietic stem cell transplantation (HSCT). While there are various barriers to IUHCT and successful donor cell engraftment, enormous progress has been made in validating this therapy in both small and large animal models. We will review the recent improvements in technique, timing, safety, donor graft content, and manipulations targeting donor cells and the host hematopoietic compartment. Many of the former barriers to IUHCT have been elucidated and surmounted, bringing us to the point at which a clinical trial may be justified. |
| Databáze: | OpenAIRE |
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