| Popis: |
Background Mice, as host animals of a variety of pathogens, can spread 60 kinds of human diseases including more than ten families of viruses including Poxviridae, Herpesviridae, and so on. Methods In this study, lung tissues and gut samples of 7-week-old mice from outdoor environments were sequenced using metagenomics, and an abundance of virome information was acquired. Results A total of 82 families of mammalian viruses, plant viruses, insect viruses, and phages were detected. Among the top 10 most abundant families were the RNA viruses Orthomyxoviridae, Picornaviridae, Bunyaviridae, and Arenaviridae, the DNA virus Herpesviridae, the insect viruses Nodaviridae and Baculoviridae, the plant virus Tombusviridae, and the phage Myoviridae. Except for Myoviridae, whose abundance in guts was higher than in lung tissues, the abundance of viruses in the lung tissues and guts showed no significant difference. Conclusions The data obtained in this study provided an overview of the viral community present in these mice samples, revealing some mouse-associated viruses closely related to known human or animal pathogens. Strengthening our understanding of unclassified viruses in mice in the natural environment could provide scientific guidance for the prevention and control of new viral outbreaks that can spread via rodents. |
