Imbalance of Circulating T-Lymphocyte Subpopulation in COPD and its Relationship with CAT Performance
| Autor: | Ye-Han Zhu, Cheng Chen, Jianan Huang, Chong-Jun Ni, Yu Shen |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty COPD business.industry Lymphocyte Biochemistry (medical) Clinical Biochemistry Public Health Environmental and Occupational Health CD4-CD8 Ratio Pulmonary disease Hematology T lymphocyte medicine.disease Gastroenterology respiratory tract diseases Medical Laboratory Technology medicine.anatomical_structure Internal medicine Immunology Copd assessment test Immunology and Allergy Medicine In patient business CD8 |
| Zdroj: | Journal of Clinical Laboratory Analysis. 26:109-114 |
| ISSN: | 0887-8013 |
| DOI: | 10.1002/jcla.21490 |
| Popis: | Chronic obstructive pulmonary disease (COPD) is associated with systemic effects, and T-cell-mediated immunity was involved in the COPD. COPD Assessment Test (CAT) could provide a valid, reliable, and standardized measure of COPD health status. The objective of this study was determination of lymphocyte subpopulation in patients with stable COPD (n = 52) and to ascertain if a relationship existed between T-lymphocyte subpopulation and CAT performance. The stable COPD patients were assessed with CAT, and divided into four groups with score >30 (n = 8), 20 30 compared to other groups. Proportion of CD4(+) cells was significantly lower in the groups with score >30 and 20 30 and 20 20. No correlations existed between proportion of CD4(+) , CD8(+) cells, CD4(+) :CD8(+) ratio, and CAT performance when score ≤20. Our results show that the determinants of T-lymphocyte subpopulation in COPD patients were value to assess physical conditions. We considered CD4(+) and CD8(+) T lymphocytes to be a representative and stable parameter in grading of health status in COPD patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|