Synthesis and Biological Evaluation of New Eugenol-Derived 1,2,3-Triazoles as Antimycobacterial Agents
| Autor: | Luiz Felipe Leomil Coelho, Thiago dos Santos, Camila de Morais Coelho, Fallon dos Santos Siqueira, Gabriel Augusto Pires de Souza, Marli Matiko Anraku de Campos, Thiago C. Elias, Diogo Teixeira Carvalho, Eloísa Salete Segatto Dalla Nora |
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| Rok vydání: | 2019 |
| Předmět: |
Mycobacterium massiliense
biology medicine.drug_class Triazole General Chemistry Mycobacterium abscessus biology.organism_classification Antimycobacterial Combinatorial chemistry Eugenol chemistry.chemical_compound Minimum inhibitory concentration chemistry medicine Mycobacterium fortuitum Mycobacterium |
| Zdroj: | Journal of the Brazilian Chemical Society. |
| ISSN: | 1678-4790 0103-5053 |
| DOI: | 10.21577/0103-5053.20190038 |
| Popis: | Eugenol has diverse biological properties including antimycobacterial activity, and the triazole ring is an important heterocycle in antimycobacterial compounds. Therefore, this research aimed to synthesize novel eugenol-derived 1,2,3-triazole as antimycobacterial agents with interesting cytotoxic profile and pharmacological assets. Sixteen compounds were obtained and characterized by nuclear magnetic resonance (NMR), infrared (IR), and high-resolution mass spectrometry (HRMS). Among them, the best growth inhibition properties from a microdilution assay were observed for three derivatives: a benzylic ether (minimum inhibitory concentration (MIC) = 48.89 µM) against Mycobacterium abscessus (ATCC 19977), an O-galactosyde (MIC = 31.76 µM) against Mycobacterium massiliense (ATCC 48898) and a sulfonate (MIC = 88.64 µM) against Mycobacterium fortuitum (ATCC 6841). They can form biofilms, and the infection progression is challenging to control due to multi-drug resistance profiles against diverse antibiotics. In conclusion, the above-mentioned compounds represent starting points in the search of bioactive molecules against mycobacteria with low cytotoxicity and better pharmacological profiles. |
| Databáze: | OpenAIRE |
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