Interleukin 1 and TLR ligands give enhanced cytokine production by their interaction with HMGB1
| Autor: | Ulf Andersson, Therese Östberg, Lena Klevenvall, Hanna Schierbeck, Heidi Wähämaa, H Sigridur Hreggvidsdottir, Ann-Charlotte Aveberger, H. Erlandsson Harris |
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| Rok vydání: | 2010 |
| Předmět: |
Lipopolysaccharide
biology business.industry medicine.medical_treatment Immunology Arthritis chemical and pharmacologic phenomena medicine.disease HMGB1 General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine chemistry.chemical_compound Mediator Cytokine Rheumatology chemistry Synovitis Rheumatoid arthritis medicine biology.protein Immunology and Allergy business |
| Zdroj: | Annals of the Rheumatic Diseases. 69:A38-A38 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2010.129627g |
| Popis: | The proinflammatory protein HMGB1 was recently identified as a mediator of rheumatoid arthritis (RA) and of other inflammatory diseases. This is demonstrated by extracellular HMGB1 expression both in experimental models of arthritis and in synovial biopsies from patients with RA. Furthermore, intra-articular injection of HMGB1 causes destructive synovitis in mice and HMGB1-targeted treatment ameliorates experimental arthritis. Recent data have indicated that HMGB1 alone does not have proinflammatory properties while complexes of HMGB1 and the TLR ligands CpG DNA and lipopolysaccharide … |
| Databáze: | OpenAIRE |
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