Hydrodynamic Influence on Sampling Systems in Bioreactors

Autor:	Gerhard Hildebrandt, Josef Metze, Ronald Schade, Gunter Gastrock, Karen Lemke
Rok vydání:	2001
Předmět:	Materials science General Chemical Engineering Ultrafiltration Analytical chemistry Sampling (statistics) General Chemistry Industrial and Manufacturing Engineering law.invention Biofouling Membrane law Bioreactor Fourier transform infrared spectroscopy Bioprocess Biological system Filtration
Zdroj:	Chemical Engineering & Technology. 24:351-354
ISSN:	1521-4125 0930-7516
Popis:	A special challenge for bioprocess technology has been interfacing new analytical equipment to the bioreactor. The main component of this interface is a sterile barrier between the biological process and the monitoring system. The connecting link is a sampling unit with micro- or ultrafiltration membranes. In order to prevent biofouling on top of the membranes, we have developed an oscillating sampling system. A model can describe the hydrodynamics, and the distribution forces in the region between membrane and medium. We compare a static sampling device to an oscillating one during a yeast cultivation process, with regard to filtration rates and the analysis of the withdrawn samples via Scanning Electron Microscopy (SEM) and Fourier Transformed Infrared Spectroscopy (FTIR). The results indicate that the oscillating sampling device shows better sampling flow behaviour.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3fce13ba3fd15080f10480a598257029 https://doi.org/10.1002/1521-4125(200104)24:4<351::aid-ceat351>3.0.co Zobrazit plný text záznamu Plný text