Semiportable electrochemical instrument for determining carbon monoxide in breath

Autor:	J E Tyson, Hendrik J. Vreman, E Wright, S Shankaran, William Oh, David K. Stevenson, James A. Lemons, S B Korones, Avroy A. Fanaroff, L L Wright
Rok vydání:	1994
Předmět:	Syringe driver chemistry.chemical_compound Chemistry Recien nacido Biochemistry (medical) Clinical Biochemistry Room air distribution Analytical chemistry Gas chromatography Electrochemistry Child health Carbon monoxide
Zdroj:	Clinical Chemistry. 40:1927-1933
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/40.10.1927
Popis:	Measurements of carbon monoxide (CO) in breath can be used for the diagnosis of hemolytic disease. A small, semiportable, easy-to-operate CO instrument was developed at Stanford University and tested at 12 Neonatal Research Network Centers of the National Institute of Child Health and Human Development. A syringe pump delivers 7.7 mL of sample per minute through an activate carbon filter to an electrochemical (EC) sensor having a sensitivity of 0.10 +/- 0.01 V per 1 microL/L CO in air. The electronically processed sensor signal is displayed on a digital multimeter. For a typical end-tidal CO measurement, corrected for inhaled CO, three 10- to 12-mL breath and room air samples are manually or mechanically collected and analyzed. CO determination in breath samples from 108 healthy, 1-day-old infants of nonsmoking mothers compared favorably with determinations by gas chromatography (GC), 1.3 +/- 0.8 vs 1.2 +/- 0.8 (mean +/- SD), respectively, with a regression equation of EC = 0.95 GC+0.13 (r2 = 0.98). The results demonstrate that the EC-CO instrument yields results that are comparable with those obtained by the more difficult to perform GC assay.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3fcc474cbea21a24a233016d8f71d4cc https://doi.org/10.1093/clinchem/40.10.1927 Zobrazit plný text záznamu