Synthesis and biological activities of peptides containing N3-(S)-2-bromosuccinamoyl-(S)-2,3-diaminopropanoic acid
| Autor: | Henryk Chmara, Ryszard Andruszkiewicz, Teresa Zieniawa, Edward Borowski |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
chemistry.chemical_classification biology Stereochemistry Organic Chemistry Antimicrobial peptides Biological activity General Medicine Tripeptide biology.organism_classification Antimicrobial In vitro Enzyme chemistry Biochemistry Enzyme inhibitor Drug Discovery biology.protein Bacteria |
| Zdroj: | European Journal of Medicinal Chemistry. 29:61-67 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/0223-5234(94)90127-9 |
| Popis: | A series of peptides with N 3 -( S )-bromosuccinamoyl-( S )-2,3-diaminopropanoic acid, a novel selective inhibitor of glucosamine-6-phosphate synthase were synthesized and evaluated in vitro for antimicrobial activity against selected bacterial and fungal strains including dermatophytes. All the peptides were found to be active against a broad range of bacteria and fungi. Tripeptides exhibited remarkable anticandidal activity. |
| Databáze: | OpenAIRE |
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