Bioactive collagen sponge as connective tissue substitute
| Autor: | Chantal DeBlois, Nancy Fournier, Charles J. Doillon, Marie-France Côté |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Materials science
biology Connective tissue Biomaterial Bioengineering Anatomy Fibroblast growth factor Fibrin Cell biology Biomaterials Extracellular matrix Fibronectin Glycosaminoglycan chemistry.chemical_compound medicine.anatomical_structure chemistry Mechanics of Materials Hyaluronic acid medicine biology.protein |
| Zdroj: | Materials Science and Engineering: C. 2:43-49 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/0928-4931(94)90028-0 |
| Popis: | Biodegradable materials such as collagen can be used as scaffold for the ingrowth of repair connective tissue. Application of interactions between extracellular matrix (ECM) molecules, growth factors and cells can be useful to design a bioactive scaffold. Studies were conducted on mice in subcutaneous implantations and in an open full-thickness wound model in pigs to investigate tissue reactions towards ECM analogues including fibrin, hyaluronic acid, fibronectin, heparin and FGF within uncrosslinked collagen sponges. In mice, subcutanous sponges impregnated with composite fibrin matrices were increasingly infiltrated by cells as a function of time. The resulting fibroblast-infiltrated tissue was close to that seen in normal connective tissue. In pigs, open wound healing was accelerated by FGF-2 and glycosaminoglycans. By 15 days, wound collagen was dense and oriented as determined by polarized light observation. Biodegradable collagen sponges in which ECM analogues have been introduced can be useful to improve cell infiltration and collagen deposition, and subsequently the healing of dermal wounds. |
| Databáze: | OpenAIRE |
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