Abolition of allogeneic inhibition of hematopoietic stem cells by treatment of recipient mice with cyclophosphamide
| Autor: | I. N. Golovistikov |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
education.field_of_study
Cyclophosphamide business.industry Population Spleen General Medicine General Biochemistry Genetics and Molecular Biology Transplantation Haematopoiesis medicine.anatomical_structure Radioresistance Immunology medicine Cancer research Bone marrow Stem cell education business medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 81:552-554 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00797567 |
| Popis: | After transplantation of bone marrow from C57BL/6 mice into lethally irradiated (CBA x C57BL/6)F1 hybrids, the degree of allogeneic inhibition of the stem cells was 92.5%. Cyclophosphamide, given to the recipients in a dose 200 mg/kg 24h before bone marrow transplantation (4 h after irradiation) reduced the degree of allogeneic inhibition to 24%. Administration of a similar dose of cyclophosphamide did not affect the number of colonies in the spleen of lethally irradiated syngeneic recipients. It is postulated that cyclophosphamide, if injected into lethally irradiated recipients acts on the population of the recipient's radioresistant cells, which are responsible for allogeneic inhibition of the stem cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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