Enhancement of Humoral and Cellular Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 by a Third Dose of BNT162b2 Vaccine in Japanese Healthcare Workers

Autor:	Kei Miyakawa, Hideaki Kato, Norihisa Ohtake, Sundararaj Stanleyraj Jeremiah, Akihide Ryo
Rok vydání:	2022
Předmět:	Infectious Diseases Immunology and Allergy
Zdroj:	The Journal of Infectious Diseases. 227:221-225
ISSN:	1537-6613 0022-1899
DOI:	10.1093/infdis/jiac344
Popis:	The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised concerns regarding vaccine effectiveness. We investigated humoral and cellular immune responses against SARS-CoV-2 in healthcare workers before and after a third (booster) dose of the BNT162b2 messenger RNA vaccine. It significantly enhanced both humoral and cellular immunity in previously uninfected individuals. However, cellular immunity was not enhanced in previously infected persons, suggesting that 3 antigenic stimuli by vaccination or natural infection reached a plateau of cellular immunity. Even with reinforced immunity to SARS-CoV-2, we confirmed several postbooster breakthrough cases caused by the Omicron variant.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3fab7de47aef316f8fd0b93ab6035954 https://doi.org/10.1093/infdis/jiac344 Zobrazit plný text záznamu