The role of striatal Gα q/11 protein in methamphetamine-induced behavioral sensitization in mice
| Autor: | Seok-Yong Lee, Kwang-Wook Lee, Hyoung-Chun Kim, Choon-Gon Jang, Kyungin Kim |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Tyrosine hydroxylase biology Chemistry Central nervous system Meth Pharmacology Methamphetamine 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Neurochemical Gq alpha subunit Neurotransmitter receptor Dopamine medicine biology.protein 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Behavioural Brain Research. 346:66-72 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2017.12.003 |
| Popis: | Gαq/11 protein transduces signals from neurotransmitter receptors and has been implicated in several functions of the central nervous system. In this study, the role of Gα q/11 protein in methamphetamine (METH)-induced behavioral sensitization was investigated using neurochemical and behavioral approaches. Repeated treatment with METH (2 mg/kg, intraperitoneally) significantly increased behavioral sensitization as well as Gαq/11 protein expression and Gα protein activity in the striata of mice, while a single treatment of METH at the same dose did not affect these parameters. Repeated intrastriatal injections of a Gα q/11 inhibitor, [D-Trp7,9,10]-substance P, significantly reduced behavioral sensitization and striatal dopamine (DA) level in response to METH, with no effect on striatal tyrosine hydroxylase expression. These results suggest that Gα q/11 protein facilitates METH-induced behavioral sensitization by modulating DA release in the mouse striatum. |
| Databáze: | OpenAIRE |
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