PPARs and pain
Autor: | Jessica C. Gaspar, Bright N. Okine, David P. Finn |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Pharmacology chemistry.chemical_classification business.industry Rat model Chronic pain Peroxisome proliferator-activated receptor Bioinformatics medicine.disease Nociceptive processing 3. Good health 03 medical and health sciences 030104 developmental biology 0302 clinical medicine chemistry Pain control Neuropathic pain Medicine Limited evidence Adverse effect business 030217 neurology & neurosurgery |
Zdroj: | British Journal of Pharmacology. 176:1421-1442 |
ISSN: | 0007-1188 |
DOI: | 10.1111/bph.14339 |
Popis: | Chronic pain is a common cause of disability worldwide and remains a global health and socio-economic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain or associated with significant adverse side effects. The PPARs, a family of nuclear hormone transcription factors, have emerged as important modulators of pain in preclinical studies and therefore a potential therapeutic target for the treatment of pain. Modulation of nociceptive processing by PPARs is likely to involve both transcription-dependent and transcription-independent mechanisms. This review presents a comprehensive overview of preclinical studies investigating the contribution of PPAR signalling to nociceptive processing in animal models of inflammatory and neuropathic pain. We examine current evidence from anatomical, molecular and pharmacological studies demonstrating a role for PPARs in pain control. We also discuss the limited evidence available from relevant clinical studies and identify areas that warrant further research. LINKED ARTICLES: This article is part of a themed section on 8th European Workshop on Cannabinoid Research. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.10/issuetoc. |
Databáze: | OpenAIRE |
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