Associations of Circulating Cytokines and Chemokines With Cancer Mortality in Men With Rheumatoid Arthritis
Autor: | E. Blair Solow, Andreas M. Reimold, Lisa A. Davis, Pascale Schwab, Jeremy Sokolove, William H. Robinson, Geoffrey M. Thiele, Gail S. Kerr, Grant W. Cannon, Brian C. Sauer, Namrata Singh, Liron Caplan, Ted R. Mikuls, Apar Kishor Ganti, Bryant R. England, Kaleb Michaud, Harlan Sayles, Josh F. Baker |
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Rok vydání: | 2016 |
Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty business.industry medicine.medical_treatment Immunology Cancer Arthritis medicine.disease National Death Index 03 medical and health sciences 0302 clinical medicine Cytokine Rheumatology 030220 oncology & carcinogenesis Rheumatoid arthritis Internal medicine medicine Immunology and Allergy Rheumatoid factor business Lung cancer Cause of death |
Zdroj: | Arthritis & Rheumatology. 68:2394-2402 |
ISSN: | 2326-5191 |
Popis: | Objective To examine the potential of circulating cytokines and chemokines as biomarkers of cancer mortality risk in patients with rheumatoid arthritis (RA). Methods Male participants in the Veterans Affairs RA registry were followed up from the time of enrollment until death or December 2013. Cytokines and chemokines were measured in banked serum obtained at the time of enrollment, using a bead-based multiplex assay, and a previously developed cytokine score was calculated. Vital status and cause of death were determined through the National Death Index. Associations of cytokines with cancer mortality were examined using multivariable competing-risks regression. Results Among 1,190 men with RA, 60 cancer deaths (30 of which were attributable to lung cancer) occurred over 5,307 patient-years of follow-up. The patients had a mean age of 64.5 years, had established disease (median duration 8.7 years), were seropositive for rheumatoid factor (81%) or anti–cyclic citrullinated peptide antibody (77%), and frequently had a history of smoking (82% current or former). Seven of 17 analytes examined were individually associated with cancer mortality. The cytokine score was associated with overall cancer (subhazard ratio [SHR] 1.42, 95% confidence interval [95% CI] 1.08–1.85) and lung cancer (SHR 1.86, 95% CI 1.57–2.19) mortality in multivariable analyses. Those in the highest quartile of cytokine scores had a >2-fold increased risk of overall cancer mortality (P = 0.039) and a 6-fold increased risk of lung cancer mortality (P = 0.028) relative to the lowest quartile. A synergistic interaction between current smoking and high cytokine score was observed. Conclusion Serum cytokines and chemokines are associated with cancer and lung cancer mortality in men with RA, independent of multiple factors including age, smoking status, and prevalent cancer. |
Databáze: | OpenAIRE |
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