Adrenogenitales Syndrom: Therapeutische Einstellung anhand des Tagesprofils des 17-Hydroxyprogesterons im Serum
| Autor: | Eberhard Nieschlag, G. Schellong, H. Breu, E. J. Wickings, H. Wenner |
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| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 105:600-603 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-2008-1070713 |
| Popis: | Radioimmunologically estimated diurnal profiles of 17-hydroxyprogesterone (17-OHP) showed clearly increased values in 15 patients with adrenogenital syndrome aged 9-19 years who had been treated for at least 4 1/2 years with cortisol. Increases were pronounced in the morning: at 8 hours 58.6 nmol/l, at 12 hours 22.2 nmol/l, at 18 hours 23.7 nmol/l on average. By changing cortisol medication, in particular due to split doses, morning 17-OHP peak values could be lowered and the whole daily profile could be improved: at 8 hours 17.9 nmol/l, at 12 hours 9.3 nmol/l, at 18 hours 8.1 nmol/l on average. The total cortisol dosage had to be increased only marginally from an average of 26.7 to 30 mg/m2 body surface, however, the evening dosage was increased from 20% to 38% on average of the total dose. Measurement of serum 17-OHP diurnal profile is thus advantageous in treatment of adrenogenital syndrome with cortisol when compared to values obtained from 24-hour urine collections. |
| Databáze: | OpenAIRE |
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