Chapter 20 Neuroendocrine and epithelial differentiation antigen expression in newly diagnosed small cell lung cancer
| Autor: | H.H. Berendsen, L. de Ley, P.E. Postmus, S. Poppema, H.J. Sluiter, T.H. The |
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| Rok vydání: | 1988 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cancer Research Pathology medicine.medical_specialty medicine.diagnostic_test medicine.drug_class business.industry Newly diagnosed Monoclonal antibody Neuroendocrine differentiation respiratory tract diseases Regimen Epithelial Differentiation Oncology Antigen Biopsy medicine Non small cell business neoplasms |
| Zdroj: | Lung Cancer. 4:84-86 |
| ISSN: | 0169-5002 |
| DOI: | 10.1016/s0169-5002(88)80022-9 |
| Popis: | A panel of monoclonal antibodies (Moab) directed against antigens related to a neuroendocrine and epithelial differentiation state, have been prospectively applied to small cell lung cancer (SCLC) biopsy specimens obtained before the induction of polychemotherapy. No differences in panel reactivity were noted between partial and complete responders. Neuroendocrine differentiation antigens were not expressed in two patients who failed to respond to the induction regimen. A third SCLC specimen without neuroendocrine differentiation antigens, was obtained from a curatively resected patient. This indicates that SCLC without neuroendocrine differentiation antigens comprises a group of tumours mimicking non-SCLC. |
| Databáze: | OpenAIRE |
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