Synthesis, cytotoxic and antioxidant activities of new n-substituted 3-(benzimidazol-2-yl)-chromones containing 2,6-di-tert-butylphenol fragment

Autor:	Eduard T. Oganesyan, Vladislav A. Tuskaev, Stanislav S. Shatokhin, Boris M. Bulychev, Alina A. Markova, Dmitry I. Pozdnyakov, Svetlana Ch. Gagieva, Elizaveta K. Melnikova
Rok vydání:	2022
Předmět:	Benzimidazole Antioxidant medicine.medical_treatment Organic Chemistry Mass spectrometry Reference drug Medicinal chemistry Analytical Chemistry Inorganic Chemistry chemistry.chemical_compound 13c nmr spectroscopy chemistry medicine Cytotoxic T cell Trolox Spectroscopy 2 6-Di-tert-butylphenol
Zdroj:	Journal of Molecular Structure. 1249:131683
ISSN:	0022-2860
Popis:	The reaction of 3-formylchromones and 4-((2-aminophenyl)imino)-2,6-di‑tert-butylcyclohexa-2,5-dienone gave a series of N-substituted benzimidazole derivatives, characterized by 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. The molecular structures of compounds 1 and 4 were determined by single crystal X-ray diffraction studies. Compounds 1–8 exhibit cytotoxic activity against human colon cancer cells HCT116 and breast cancer cells MCF7 at submicromolar concentrations. Compound 6 is more active against tumor cells than non-malignant fibroblasts. Compounds 1, 3, 5 and 7 exhibit antioxidant activity comparable to the reference drug Trolox.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3f876211b7452b12db8693cd62081813 https://doi.org/10.1016/j.molstruc.2021.131683 Zobrazit plný text záznamu Full Text from ScienceDirect