Pharmacokinetic study of Cepharanthin following single oral doses in healthy subjects

Autor:	Akihiro Ohnishi, Michio Tsunoo, Michinori Akasu, Mitsuo Moro, Akira Shishido, Kohtaro Yasuda
Rok vydání:	1989
Předmět:	Pharmacology Side effect business.industry Alkaloid Healthy subjects Cmax Urine Urinary excretion Pharmacokinetics Cepharanthin Medicine Pharmacology (medical) business
Zdroj:	Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 20:735-740
ISSN:	1882-8272 0388-1601
Popis:	The pharmacokinetic disposition of Cepharanthin, a biscoclaurine alkaloid, was investigatedin healthy subjects following single oral doses of 10, 30, 60, and 120mg. For 30, 60, and 120mg, 5 subjects were studied for each dose ; for 10 mg, only 2 subjects were studied.Plasma and urine Cepharanthin levels were measured by the HPLC method and wereanalyzed by the one-compartment open model. Linear relationships were obtained betweenthe dose from 10 to 120mg of Cepharanthin and the Cmax or the AUC. The Tmax and thet1/2 ranged from 1.1 to 2.5 hr and from 4.1 to 9.2 hr (t1/2α: 3.3 ± 1.0 ; t1/2β: 17.1 ± 4.1 hrin 120mg), respectively. The mean (±SE) of percent urinary excretion of unchanged drugwas 1.4 ± 0.3%. No side effect has been observed throughout the study period.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3f840bf2c8bc5bbc1b55d1c3322ff415 https://doi.org/10.3999/jscpt.20.735 Zobrazit plný text záznamu