Modified Physicochemical Properties of Acidic Model Drugs Immobilized on Fe3O4Magnetic Iron Oxide Nanoparticles

Autor:	Alicja Defort, Julia Nowak-Jary, Jacek Juliusz Kozioƚ
Rok vydání:	2020
Předmět:	Pharmacology 010405 organic chemistry 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Dynamic light scattering Permeability (electromagnetism) Drug Discovery Drug delivery Lipophilicity Solubility Drug carrier Dissolution Iron oxide nanoparticles Nuclear chemistry
Zdroj:	Pharmaceutical Chemistry Journal. 53:1025-1035
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-020-02118-w
Popis:	Nanoparticles are now extensively evaluated as drug carriers. The main objective of the present work was to evaluate the difference in physicochemical properties (solubility, permeability, lipophilicity) between acidic drugs immobilized on magnetic iron oxide nanoparticles and the same drugs in their unbound form. Synthesis of Fe3O4 magnetic iron oxide nanoparticles coated with (3-aminopropyl)triethoxysilane (APTES) was carried out with the chosen drugs attached. The obtained nanostructures were characterized using IR spectroscopy, atomic force microscopy (AFM), vibrating sample magnetometry (VSM) and dynamic light scattering (DLS) techniques, and physicochemical properties of the immobilized drugs were studied. The drug solubility was measured using the saturation shake-flask method. The permeability was measured using dialysis membranes, MWCO 50 kD with pores
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3f816a1423003fb79a841f1211386595 https://doi.org/10.1007/s11094-020-02118-w Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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