Sonothromblysis in Combination with Thrombolytic Drugs in a Rabbit Model Using MRI-Guidance

Autor:	Nicos Mylonas, Christakis Damianou, Kleanthis Ioannides
Rok vydání:	2013
Předmět:	Tissue temperature medicine.diagnostic_test business.industry medicine.medical_treatment Ultrasound Thrombolysis medicine.disease Magnetic resonance angiography Thrombolytic drug In vivo medicine Rabbit model business Stroke Biomedical engineering
Zdroj:	Engineering. :352-356
ISSN:	1947-394X 1947-3931
DOI:	10.4236/eng.2013.510b071
Popis:	The potential of MRI-guided focused ultrasound (MRgFUS) combined with the thrombolytic drug recombinant tissue plasminogen activator (rt-PA), to dissolve clots in the carotid of a New Zealand rabbitin vivois evaluated. A spherically-focused transducers of 5 cmdiameter; focusing at10 cmand operating at 1 MHz was used. A pulsed ultrasound protocol was used that maintains a tissue temperature increase of less than 1℃ in the clot (called safe temperature). MRgFUS has the potentials to dissolve clots that are injected in the carotid of rabbits in vivo. It was found that the time needed for opening the carotid artery using ultrasound and rt-PA was decreased compared to just using rt-PA. The proposed protocol was monitored using Magnetic Resonance Angiography (MRA) every 1 min.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3f7daaa0d119bf0446f3841506f5dafe https://doi.org/10.4236/eng.2013.510b071 Zobrazit plný text záznamu