Altered collagen synthesis in fascia transversalis of patients with inguinal hernia

Autor:	Z.Y. Si, Bernd Klosterhalfen, H. Zheng, Volker Schumpelick, R.S. Bhardwaj, Uwe Klinge
Rok vydání:	1999
Předmět:	Pathology medicine.medical_specialty business.industry medicine.medical_treatment Transverse fascia Hernia repair medicine.disease Pathophysiology Surgery Collagen Type III Inguinal hernia medicine.anatomical_structure Surgical mesh medicine Immunohistochemistry Hernia business
Zdroj:	Hernia. 3:181-187
ISSN:	1248-9204 1265-4906
DOI:	10.1007/bf01194422
Popis:	The aim of this study was to substantiate the hypothesis as to whether an altered metabolism of type I and type III collagen should be included as pathophysiological considerations of inguinal hernia development or not. Therefore, fascia transversalis derived from patients with indirect hernias (n=9), direct hernias (n=7) and from controls (n=7) were investigated both by immunohistochemistry and protein analysis (Western Blot). Both immunohistochemical analysis and Western Blot analysis showed that the ratio of the relative amounts of type I to type III collagen was significantly decreased in the fascia transversalis of patients with indirect and direct inguinal hernias compared with controls (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3f77b70534eadc4eaebba19ec57b7081 https://doi.org/10.1007/bf01194422 Zobrazit plný text záznamu Full text from SpringerLink