ChemInform Abstract: Synthesis and Evaluation of Artificial Taxoids with Antitumor and Multi-Drug Resistance Reversing Activities

Autor:	Isao Kuwajima, Koichiro Morihira, Hiroyuki Kusama, Toshiyuki Nishimori, Yoshiaki Horiguchi, Takashi Tsuruo
Rok vydání:	2010
Předmět:	Vincristine Tumor cells General Medicine Drug resistance Pharmacology Terpene Taxoid chemistry.chemical_compound chemistry Cancer cell medicine Reversing Growth inhibition medicine.drug
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199911203
Popis:	Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3f6eed55ef90fde2d728c9d2cdbcf4e4 https://doi.org/10.1002/chin.199911203 Zobrazit plný text záznamu Plný text