Interleukin-6 Modulates Plasma Cholesterol and C-Reactive Protein Concentrations in Nonagenarians
| Autor: | Erkki Wuolijoki, Riikka Rontu, Mikko Hurme, Petri Ojala, Hannu Jokela, Marja Jylhä, Pekka J. Karhunen, Terho Lehtimäki, Saara Metso, and Antti Hervonen Md, Sirkka Goebeler, Matti Nikkilä, Kari Mattila |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
biology Cholesterol business.industry C-reactive protein Systemic inflammation Oldest old chemistry.chemical_compound Endocrinology chemistry Plasma cholesterol Plasma total cholesterol Internal medicine biology.protein Medicine Geriatrics and Gerontology medicine.symptom business Interleukin 6 High sensitive crp |
| Zdroj: | Journal of the American Geriatrics Society. 53:1552-1558 |
| ISSN: | 1532-5415 0002-8614 |
| DOI: | 10.1111/j.1532-5415.2005.53484.x |
| Popis: | OBJECTIVES: To establish whether the relationship between interleukin-6 (IL-6) and plasma lipid and C-reactive protein (CRP) concentrations is different in Finnish nonagenarians than in middle-aged subjects with lower inflammatory status. DESIGN: Cross-sectional. SETTING: Observational cohort study concentrating on the oldest old. PARTICIPANTS: Nonagenarians (n = 291, mean age ± standard deviation 90 ± 1; 68 men, 223 women) who lived in the Tampere municipality in southern Finland and a middle-aged control population from the same area (n = 227, aged 44 ± 8). MEASUREMENTS: Plasma high sensitive CRP and lipid concentrations were analyzed using an automatic analyzer and IL-6 levels using enzyme-linked immunosorbent assay. RESULTS: Plasma concentrations of IL-6 (4.39 ± 5.25 vs 1.88 ± 1.98 pg/mL) and CRP (3.54 ± 4.98 vs 1.53 ± 1.91 mg/L) were significantly higher in nonagenarians than in middle-aged subjects (P |
| Databáze: | OpenAIRE |
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