Correlation between affinity of antidepressants for membranes and their effect on neuromediator reassimilation

Autor:	A. V. Val'dman, N. A. Avdulov, G. E. Dobretsov
Rok vydání:	1981
Předmět:	chemistry.chemical_classification Liposome Chemistry Membrane lipids Chemical structure Biological membrane General Medicine General Biochemistry Genetics and Molecular Biology Membrane Mechanism of action medicine Biophysics medicine.symptom Lipid bilayer Tricyclic
Zdroj:	Bulletin of Experimental Biology and Medicine. 92:1054-1056
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00829781
Popis:	An important component of the mechanism of action of the tricyclic antidepressants is their ability to inhibit reassimilation of neuromediators by nerve endings. In recent years new effective antidepressants have been produced which differ significantly from the tricyclic compounds, not only in chemical structure, but also in pharmacological properties, including their effect on neuromediator uptake [6]. The molecular mechanisms of mediator uptake have not been adequately studied. The writers have suggested that inhibition of reassimilation by antidepressants is connected with the affinity of the lipophilic molecules of these compounds for biological presynaptic membranes. According to the liquid-mosaic model of the biological membrane [9], its principal structural determinants are the asymmetrical phospholipid bilayer and granular proteins. Activity of the Na,K-ATPase, with which the transport (uptake) of neuromediators is coupled, is essentially modulated by changes in the state of the membrane lipids [8].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3f69925355fcf6920eacb16250151465 https://doi.org/10.1007/bf00829781 Zobrazit plný text záznamu Full text from SpringerLink