Blood-Brain Barrier Integrity and Clearance of Amyloid-β from the BBB
| Autor: | Huaxi Xu, Donghui Zhu, Joy-anne N. Oliver, Irsalan Cockerill, Bingmei M. Fu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
education.field_of_study Amyloid β business.industry Population Cognition Dysfunctional family Disease medicine.disease Blood–brain barrier Protective barrier 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure medicine Dementia education business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9783319964447 |
| DOI: | 10.1007/978-3-319-96445-4_14 |
| Popis: | Alzheimer’s disease, a type of dementia, affects memory, behavior, and cognitive processes in affected individuals. It is one of the prominent diseases, accounting for 60–80% of dementia cases and affecting a significant population of persons over the age of 65 years. While rare, Alzheimer’s disease (AD) may affect the younger population as well. With such a widespread number of persons affected with AD, scientists have undertaken the initiative to develop a cure for this devastating disease; however, it has been deemed quite challenging. A dysfunctional blood-brain barrier, with impaired ability to clear amyloid-β from the brain, has been directly linked to the development of Alzheimer’s disease. The blood-brain barrier restricts the flow of many substances into and out of the brain and serves as a selective and protective barrier to the brain. A proper functioning blood-brain barrier contributes to the maintenance and integrity of the brain. In turn, different systems and mechanisms within the blood-brain barrier are set in place to facilitate mediated passage of materials and substances between the brain and the bloodstream. In relation to AD, the mediation of amyloid-β clearance is of great importance in maintaining the blood-brain barrier’s integrity. |
| Databáze: | OpenAIRE |
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