Costimulatory Molecules OX40 and OX40L Upregulation in Oral Squamous Cell Carcinoma: A Blood-Based Study
| Autor: | Aliya Irshad Sani, Zila Rubab, Shumaila Usman, Syed Zaryab Ahmed, Sadia Arif |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | European Journal of Dentistry. |
| ISSN: | 1305-7464 1305-7456 |
| DOI: | 10.1055/s-0042-1760375 |
| Popis: | Objectives This research aimed to determine OX40 and OX40L mRNA expression in blood samples of naive oral squamous cell carcinoma (OSCC) patients in different histological grades and clinical stages. The in silico analysis was performed using the STRING database for functional association and a better understanding of the interactions of OX40 and its ligand with other proteins. Materials and Methods In this study, we recruited 141 newly diagnosed patients of OSCC. Levels of OX40 and OX40L mRNA expression were explored using real-time quantitative polymerase chain reaction. An in silico tool was also utilized to evaluate the OX40/OX40L interactome. Results The results showed higher OX40 expressional levels in the late stage (23-fold) compared with the early stage (8.5-fold) (p = Conclusion Based on current study findings, despite OX40 and OX40L upregulation in newly diagnosed OSCC patients, it is speculated that the physiological function of these molecules is altered due to immune system exhaustion. |
| Databáze: | OpenAIRE |
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