Lamotrigine as an adjuvant treatment for acute bipolar depression: A Brazilian naturalistic study
| Autor: | Elie Cheniaux, Ana Letícia Santos Nunes, Rafaela Oliveira da Silva, Fernanda Novis, P Coscarelli, Luciana Angélica Silva Silveira |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Bipolar I disorder medicine.drug_class General Neuroscience Hamilton Rating Scale for Depression Mood stabilizer Lamotrigine Young Mania Rating Scale medicine.disease Neuropsychology and Physiological Psychology Hypomania Internal medicine mental disorders medicine medicine.symptom Psychiatry Psychology Mania Depression (differential diagnoses) medicine.drug |
| Zdroj: | Psychology & Neuroscience. 6:109-113 |
| ISSN: | 1983-3288 1984-3054 |
| DOI: | 10.3922/j.psns.2013.1.16 |
| Popis: | is indicated according to several recent treatment guidelines as a first-line medication for the treatment of bipolar depression. However, its efficacy in acute bipolar depression has not been well established. In the present naturalistic study, patients with bipolar depression (n = 20), predominantly bipolar type I, were treated with lamotrigine in addition to their prior treatment for 8 weeks. The Young Mania Rating Scale (YMRS), 17-item Hamilton Rating Scale for Depression (HAM-D-17), and Clinical Global Impressions-Bipolar Disorder (CGI-BD) scale were applied at baseline, week 4, and week 8. With regard to the primary measure of efficacy, mean total HAM-D-17 scores significantly decreased (p < .01) at the end of treatment. Eight patients (40%) exhibited a positive response (i.e., at least a 50% reduction of baseline scores). Additionally, eight (40%) and 11 (55%) patients exhibited complete remission, reflected by HAM-D-17 and CGI-BP scores, respectively. Episodes of switching to mania or hypomania occurred in five patients (25%). No skin rash or any other significant adverse events were reported. Our results indicate that the addition of lamotrigine to a mood stabilizer can be useful in the treatment of acute depressive episodes in bipolar I disorder. |
| Databáze: | OpenAIRE |
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