Effect of Oligochitosan on Experimental Venous Thrombosis in Guinea Pigs

Autor:	Valery P. Varlamov, A. V. Il’ina, N N Drozd, B. Ts. Shagdarova
Rok vydání:	2021
Předmět:	Platelet aggregation General Medicine Heparin Pharmacology medicine.disease Anticoagulant activity General Biochemistry Genetics and Molecular Biology Hemolysis In vitro Chitosan chemistry.chemical_compound Venous thrombosis chemistry Antithrombotic medicine medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 172:33-37
ISSN:	1573-8221 0007-4888
DOI:	10.1007/s10517-021-05325-x
Popis:	Oligochitosan Сh10/85 with a molecular weight of 10 kDa and a deacetylation degree of 85% prevented the development of experimental venous thrombosis in guinea pigs after intravenous administration in a dose of 30 mg/kg. In a concentration of 0.005-0.5 mg/ml, oligochitosan Ch10/85 did not provoke hemolysis of human red blood cells in in vitro experiments. The antithrombotic effect of oligochitosan Ch10/85 that exhibits low anticoagulant activity (by two orders of magnitude lower than that of unfractionated heparin) can be associated with inhibition of platelet aggregation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3f56edf50edfa5d11cd8947f011c660c https://doi.org/10.1007/s10517-021-05325-x Zobrazit plný text záznamu Full text from SpringerLink