DNA Topoisomerase Inhibitory Activity of Constituents from the Fruits of Illicium verum
| Autor: | Bora Shin, Chong Soon Lee, Hyukjae Choi, Mi Hee Woo, Dong-Chan Oh, Geum Jin Kim, Jong Keun Son, Tae In Kim |
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| Rok vydání: | 2017 |
| Předmět: |
Circular dichroism
food.ingredient biology Stereochemistry medicine.drug_class Chemistry Chemical structure Topoisomerase Illiciaceae General Chemistry General Medicine Nuclear magnetic resonance spectroscopy biology.organism_classification food Illicium Drug Discovery biology.protein medicine Illicium verum Topoisomerase inhibitor |
| Zdroj: | CHEMICAL & PHARMACEUTICAL BULLETIN. 65:1179-1184 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Three new compounds, a sesquilignan (1) and two glucosylated phenylpropanoids (2, 3), and seven known compounds (4-10), were isolated from the fruits of Illicium verum HOOK. FIL. (Illiciaceae). The structures of 1-3 were determined based on one and two dimensional (1D- and 2D-) NMR data and electronic circular dichroism (ECD) spectra analyses. Compounds 3, 5, 6, and 8-10 exhibited potent inhibitory activities against topoisomerase II with IC50 values of 54.6, 25.5, 17.9, 12.1, 0.3 and 1.0 µM, respectively, compared to etoposide, the positive control, with an IC50 of 43.8 µM. |
| Databáze: | OpenAIRE |
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